ACS Med Chem Lett. 2025 Jan 23;16(3):363-365. doi: 10.1021/acsmedchemlett.5c00011. eCollection 2025 Mar 13.ABSTRACTThis patent application pertains to macrocyclic peptides, generally represented by Formula I. These compounds exhibit selective binding to tumor necrosis factor receptor 1 (TNFR1) and h
Acta Clin Croat. 2024 Oct;63(2):431-435. doi: 10.20471/acc.2024.63.02.21.ABSTRACTProlonged cocaine inhalation can cause destruction of nasal mucosa and ethmoid sinuses and palate perforation, thus inducing cocaine-induced midline destructive lesions (CIMDL) that affect only a limited number of predi
Front Immunol. 2025 Mar 4;16:1476563. doi: 10.3389/fimmu.2025.1476563. eCollection 2025.ABSTRACTBACKGROUND: Drug-induced immune hemolytic anemia (DIIHA) is a rare but serious disease associated with various antibiotics, which is often misdiagnosed. DIIHA often leads to adverse outcomes, including or
Ibrain. 2025 Jan 7;11(1):98-105. doi: 10.1002/ibra.12191. eCollection 2025 Spring.ABSTRACTThis study aimed to investigate the causal relationship between systemic lupus erythematosus (SLE) and juvenile myoclonic epilepsy (JME). Univariable and reverse Mendelian randomization (MR) analyses were perfo
Toxicol Res (Camb). 2025 Mar 17;14(2):tfaf036. doi: 10.1093/toxres/tfaf036. eCollection 2025 Apr.ABSTRACTAutoimmune hepatitis (AIH) is an autoimmune disease mediated by abnormal autoimmune. The pathogenesis and pathological manifestation of immune-mediated liver injury, induced by concanavalin A (Co
Adv Mater. 2025 Mar 19:e2500883. doi: 10.1002/adma.202500883. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a chronic autoimmune disease characterized by excessive inflammation, pathological bone resorption, and systemic osteoporosis. It lacks effective treatment due to the complex path
Respir Res. 2025 Mar 18;26(1):106. doi: 10.1186/s12931-025-03169-x.ABSTRACTBACKGROUND: Systemic lupus erythematosus (SLE) is an autoimmune disease that involves multi-organ damage. Pulmonary arterial hypertension (PAH) is one of the life-threatening complications of SLE. The underlying cause of syst
An Bras Dermatol. 2025 Mar 17:S0365-0596(25)00027-3. doi: 10.1016/j.abd.2024.07.015. Online ahead of print.ABSTRACTBACKGROUND: Pemphigus is an autoimmune blistering disease where autoantibodies target desmoglein (Dsg) antigens on keratinocytes, triggering the p38 MAPK pathway, Dsg internalization, d
J Clin Rheumatol. 2025 Mar 19. doi: 10.1097/RHU.0000000000002230. Online ahead of print.ABSTRACTBACKGROUND: Idiopathic inflammatory myopathies (IIMs) are rare autoimmune diseases with limited epidemiological data from Latin America.OBJECTIVE: To characterize IIMs through incident rate patterns and c
Br J Clin Pharmacol. 2025 Mar 18. doi: 10.1002/bcp.70047. Online ahead of print.ABSTRACTThiopurines are a class of immunosuppressant and antineoplastic agents. They are widely used in the treatment of inflammatory bowel disease, haematological malignancies and autoimmune diseases, but can cause sign
ACS Nano. 2025 Mar 18. doi: 10.1021/acsnano.4c18345. Online ahead of print.ABSTRACTTissue-resident macrophages (TRMs) are attractive cells to therapeutically deliver oligonucleotide and other gene-expression modifying modalities to treat a wide array of diseases ranging from inflammatory to autoimmu
Vet Res Forum. 2025;16(2):117-124. doi: 10.30466/vrf.2024.2031860.4316. Epub 2025 Feb 15.ABSTRACTThis study evaluated the impact of combining piperine and prednisolone on clinical symptoms and immune responses in Wistar rats with rheumatoid arthritis (RA) induced by Freund's complete adjuvant due to
Food Sci Nutr. 2025 Mar 16;13(3):e70068. doi: 10.1002/fsn3.70068. eCollection 2025 Mar.ABSTRACTRheumatoid arthritis (RA) is a prevalent and debilitating autoimmune disease. Numerous studies have demonstrated promising results regarding the use of probiotics as a therapeutic approach to alleviate RA
Cureus. 2025 Feb 15;17(2):e79051. doi: 10.7759/cureus.79051. eCollection 2025 Feb.ABSTRACTPyoderma gangrenosum (PG) is a rare, immune-mediated neutrophilic dermatosis, presenting with painful ulcerative skin lesions. These lesions often start as pustules on an erythematous base, progressing to large
Inflammatory Bowel Disease (IBD) is an autoimmune disease characterized by chronic relapsing inflammation of the intestinal tract. Gut microbiota (GM) and CD4^(+)T cells are important in the development of IBD. A lot of studies have shown that GM and their metabolites like short-chain fatty acids, b
Front Immunol. 2025 Mar 3;16:1511902. doi: 10.3389/fimmu.2025.1511902. eCollection 2025.ABSTRACTINTRODUCTION: Alterations of the adaptive immune system have been shown to impact bone healing and may result in impaired healing in some patients. Apart from T cells, B cells are the key drivers of adapt
Drug Des Devel Ther. 2025 Mar 11;19:1721-1739. doi: 10.2147/DDDT.S501773. eCollection 2025.ABSTRACTAutoimmune diseases arise when the immune system attacks healthy tissues, losing tolerance for self-tissues. Normally, the immune system recognizes and defends against pathogens like bacteria and virus
Kidney Dis (Basel). 2025 Feb 5;11(1):75-89. doi: 10.1159/000543940. eCollection 2025 Jan-Dec.ABSTRACTINTRODUCTION: Fatty acid-binding protein 4 (FABP4) is a novel adipokine that is critically involved in many inflammatory and immune diseases. However, the role of FABP4 in antineutrophil cytoplasmic
Praxis (Bern 1994). 2025 Mar;114(3):105-110. doi: 10.23785/PRAXIS.2025.03.006.ABSTRACTRheumatoid arthritis (RA) is the most common chronic inflammatory autoimmune disease in Switzerland, affecting up to 1 % of patients. Accordingly, these patients are also frequently seen in general practitioner con
Arthritis Rheumatol. 2025 Mar 17. doi: 10.1002/art.43157. Online ahead of print.ABSTRACTOBJECTIVE: Disordered T peripheral helper (Tph)-B cell interactions have been implicated in several forms of inflammatory arthritis, including oligoarticular juvenile idiopathic arthritis (oligo JIA). We sought t
Acta Biomater. 2025 Mar 15:S1742-7061(25)00197-7. doi: 10.1016/j.actbio.2025.03.023. Online ahead of print.ABSTRACTCurrent immunosuppressive therapies for rheumatoid arthritis (RA) lack disease specificity, primarily targeting inflammation while causing debilitating side effects. To address this lim
Exp Cell Res. 2025 Mar 15:114518. doi: 10.1016/j.yexcr.2025.114518. Online ahead of print.ABSTRACTBACKGROUND: Non-alcoholic fatty liver disease (NAFLD), along with non-alcoholic steatohepatitis (NASH), lacks definitive therapy and typically remains asymptomatic until reaching advanced stages. Lipid
Int Immunopharmacol. 2025 Mar 16;152:114452. doi: 10.1016/j.intimp.2025.114452. Online ahead of print.ABSTRACTMesenchymal stem cell derived extracellular vesicles (MSC-EVs) are key paracrine mediators involved in various autoimmune diseases. While current research on EVs predominantly focuses on the
J Clin Med. 2025 Mar 5;14(5):1745. doi: 10.3390/jcm14051745.ABSTRACTDeucravacitinib is an allosteric, selective tyrosine kinase 2 (TYK2) inhibitor that has demonstrated significant efficacy in the treatment of psoriasis. TYK2, a member of the Janus kinase (JAK) family, plays a critical role in intra
