Epilepsia. 2025 Mar;66 Suppl 1:29-37. doi: 10.1111/epi.18303.ABSTRACTMost people with epilepsy are able to achieve good seizure control with currently available medications. However, despite the development of more than 20 new antiseizure medications (ASMs) over the past 30 years, approximately one
Adv Ther. 2025 Mar 18. doi: 10.1007/s12325-025-03159-x. Online ahead of print.ABSTRACTINTRODUCTION: This study explored patient and clinician perspectives on a new fixed-dose combination of macitentan and tadalafil (M/T FDC) in a once-daily single tablet for treatment of pulmonary arterial hypertens
Age Ageing. 2025 Mar 3;54(3):afaf057. doi: 10.1093/ageing/afaf057.ABSTRACTOBJECTIVE: This scoping review aimed to identify predictive factors influencing gait recovery post-hip fracture surgery among adults aged 65 and older.DESIGN: A systematic search of MEDLINE, Embase and CINAHL databases was con
Dermatol Ther (Heidelb). 2025 Mar 17. doi: 10.1007/s13555-025-01376-4. Online ahead of print.ABSTRACTINTRODUCTION: Patients with chronic urticaria (CU) may have different clinical courses of disease including periods of active CU, clinical remission, and relapse. The objective of this study was to d
Eur J Heart Fail. 2025 Mar 17. doi: 10.1002/ejhf.3642. Online ahead of print.ABSTRACTThe multiplicity of coexisting comorbidities affecting patients with heart failure (HF), together with the availability of multiple treatments improving prognosis in HF with reduced ejection fraction, has led to an
Psychogeriatrics. 2025 May;25(3):e70018. doi: 10.1111/psyg.70018.ABSTRACTBACKGROUND: We prospectively examined the prevalence, co-existence, and change of geriatric giant syndromes in older people over 2 years.METHODS: Two hundred and five older subjects were examined before and after 2 years. Ten g
Geroscience. 2025 Mar 13. doi: 10.1007/s11357-025-01586-w. Online ahead of print.ABSTRACTPolypharmacy is common among older adults and has been linked to adverse outcomes such as dementia, Parkinson's disease (PD), and mortality. However, its influence on transitions between these health states rema
Diabetes Metab J. 2025 Mar;49(2):183-193. doi: 10.4093/dmj.2024.0836. Epub 2025 Mar 1.ABSTRACTBACKGRUOUND: Diabetes in older adults is becoming a significant public burden to South Korea. However, a comprehensive understanding of epidemiologic trends and the detailed clinical characteristics of olde
Pain Ther. 2025 Mar 12. doi: 10.1007/s40122-025-00720-y. Online ahead of print.ABSTRACTINTRODUCTION: Opioid-induced constipation (OIC) is a common side effect of chronic opioid therapy that significantly impacts quality of life and healthcare costs. Naldemedine, a peripherally acting mu-opioid recep
Front Pain Res (Lausanne). 2025 Feb 21;6:1512878. doi: 10.3389/fpain.2025.1512878. eCollection 2025.ABSTRACTINTRODUCTION: Excessive polypharmacy, which can be defined as the concurrent use of ≥10 medications, is prevalent among individuals with chronic pain. However, it remains unclear how it may va
South Asian J Cancer. 2025 Feb 14;13(4):281-286. doi: 10.1055/s-0045-1802564. eCollection 2024 Oct.ABSTRACTA significant number of patients with colorectal cancer (CRC) benefit from adjuvant therapy. While 6 months of FOLFOX is standard of care, newer regimens like CAPOX and SOX allow for shorter du
J Geriatr Oncol. 2025 Mar 8;16(3):102219. doi: 10.1016/j.jgo.2025.102219. Online ahead of print.ABSTRACTINTRODUCTION: Chronic lymphocytic leukemia (CLL) particularly impacts older adults with multiple comorbidities. The advent of targeted therapies has improved outcomes, but challenges related to tr
Minerva Cardiol Angiol. 2025 Mar 6. doi: 10.23736/S2724-5683.24.06808-X. Online ahead of print.ABSTRACTThe integration of artificial intelligence (AI) into healthcare is transforming medical practice, and this holds true also for the prevention, diagnosis and treatment of cardiovascular disease in o
BMJ Open Diabetes Res Care. 2025 Mar 5;13(2):e004312. doi: 10.1136/bmjdrc-2024-004312.ABSTRACTINTRODUCTION: Women with type 2 diabetes are at risk of commencing pregnancy while using medications that are either not recommended for pregnancy or with known teratogenicity, which may contribute to adver
J Brown Hosp Med. 2024 Jul 1;3(3):120951. doi: 10.56305/001c.120951. eCollection 2024.ABSTRACTCannabis has been employed medicinally throughout history, with recent renewed interest for use due to media awareness and medical marijuana legislation. The geriatric population, identified as those 65 yea
Aging Male. 2025 Dec;28(1):2469614. doi: 10.1080/13685538.2025.2469614. Epub 2025 Mar 1.ABSTRACTBACKGROUND AND OBJECTIVES: Type 2 diabetes mellitus (T2DM) is a common chronic disease in the elderly. Comorbidities, especially neuropathy and retinopathy, significantly increase fall risk in this group.
RMD Open. 2025 Feb 27;11(1):e005280. doi: 10.1136/rmdopen-2024-005280.ABSTRACTResearch in older adults diagnosed with rheumatic and musculoskeletal diseases (RMDs) comes with unique challenges, as these patients often face consequences of ageing, such as multimorbidity, polypharmacy, and geriatric s
Breast. 2025 Feb 23;80:104428. doi: 10.1016/j.breast.2025.104428. Online ahead of print.ABSTRACTBreast cancer remains a leading cause of cancer-related mortality worldwide, with elderly patients (aged >65 years) comprising a substantial portion of those affected. The treatment of breast cancer in th
Joint Bone Spine. 2025 Feb 24:105864. doi: 10.1016/j.jbspin.2025.105864. Online ahead of print.ABSTRACTRecent data suggest a pathophysiological role of aging and immuno-senescence during polymyalgia rheumatica (PMR) and giant cell arteritis (GCA), by definition rheumatic disease of the elderly. Duri
Medicina (Kaunas). 2025 Feb 14;61(2):336. doi: 10.3390/medicina61020336.ABSTRACTBackground and Objectives: Postoperative delirium (POD) is a transient but significant complication in geriatric patients following hip or femur surgery. POD occurs in 19-65% of patients after hip surgeries, with notable
J Clin Med. 2025 Feb 19;14(4):1383. doi: 10.3390/jcm14041383.ABSTRACTBackground: Patients with peripheral artery disease (PAD) and diabetes face high risks of comorbidities, tissue loss, and cardiovascular events. As global type 2 diabetes (T2DM) prevalence rises, so does its incidence in symptomati
Life (Basel). 2025 Jan 31;15(2):215. doi: 10.3390/life15020215.ABSTRACTComplete atrioventricular (AV) block is a severe conduction abnormality caused by intrinsic cardiac disease, ischemia, electrolyte imbalances, or drug interactions. Elderly patients on multiple medications are particularly vulner
Semin Neurol. 2025 Feb 24. doi: 10.1055/a-2534-3267. Online ahead of print.ABSTRACTDevelopmental and epileptic encephalopathies (DEEs) are a group of rare, severe, early-onset epilepsies characterized by pharmacoresistance, marked electroencephalographic abnormalities, and delayed or regressive psyc
Medicine (Baltimore). 2025 Feb 21;104(8):e41635. doi: 10.1097/MD.0000000000041635.ABSTRACTThe aim of this study is to compare frailty screening tools in predicting length of stay (LOS) in older patients on internal medicine inpatient wards transferred from the emergency department (ED). This cross-s
